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D440N Mutation in the Acid-Labile Subunit of Insulin-Like Growth Factor Complexes Inhibits Secretion and Complex Formation
The acid-labile subunit (ALS) regulates IGF bioavailability by forming heterotrimeric complexes with IGFs and IGF-binding protein-3 (IGFBP-3). A homozygous missense mutation (D440N) resulting in undetectable circulating levels of ALS with a concomitant reduction in IGF-I and IGFBP-3 has been reporte...
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| Publicado en: | Mol Endocrinol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Endocrine Society
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417311/ https://ncbi.nlm.nih.gov/pubmed/21177759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0295 |
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