Ablation of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) in Vascular Endothelial Cells Enhances Insulin Sensitivity by Reducing Visceral Fat and Suppressing Angiogenesis

The phosphatidylinositol 3-kinase signaling pathway in vascular endothelial cells is important for systemic angiogenesis and glucose metabolism. In this study, we addressed the precise role of the 3-phosphoinositide-dependent protein kinase 1 (PDK1)-regulated signaling network in endothelial cells i...

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Dades bibliogràfiques
Publicat a:Mol Endocrinol
Autors principals: Tawaramoto, Kazuhito, Kotani, Ko, Hashiramoto, Mitsuru, Kanda, Yukiko, Nagare, Tomoki, Sakaue, Hiroshi, Ogawa, Wataru, Emoto, Noriaki, Yanagisawa, Masashi, Noda, Tetsuo, Kasuga, Masato, Kaku, Kohei
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417157/
https://ncbi.nlm.nih.gov/pubmed/22108800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0412
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