Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARγ agonist

Pioglitazone preserves pancreatic β-cell morphology and function in diabetic animal models. In this study, we investigated the molecular mechanisms by which pioglitazone protects β-cells in diabetic db/db mice. In addition to the morphological analysis of the islets, gene expression profiles of the...

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Detalhes bibliográficos
Main Authors: Kanda, Yukiko, Shimoda, Masashi, Hamamoto, Sumiko, Tawaramoto, Kazuhito, Kawasaki, Fumiko, Hashiramoto, Mitsuru, Nakashima, Koji, Matsuki, Michihiro, Kaku, Kohei
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822485/
https://ncbi.nlm.nih.gov/pubmed/19920213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00388.2009
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