Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders

In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl(−))(i) levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide reduced the severity of ASD i...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Lemonnier, E, Villeneuve, N, Sonie, S, Serret, S, Rosier, A, Roue, M, Brosset, P, Viellard, M, Bernoux, D, Rondeau, S, Thummler, S, Ravel, D, Ben-Ari, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416661/
https://ncbi.nlm.nih.gov/pubmed/28291262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.10
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