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Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders
In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl(−))(i) levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide reduced the severity of ASD i...
Tallennettuna:
| Julkaisussa: | Transl Psychiatry |
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| Päätekijät: | , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5416661/ https://ncbi.nlm.nih.gov/pubmed/28291262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.10 |
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