A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation

The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling. Here we revealed significant upregulation of prorenin...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Kanda, Atsuhiro, Ishizuka, Erdal Tan, Shibata, Atsushi, Matsumoto, Takahiro, Toyofuku, Hidekazu, Noda, Kousuke, Namba, Kenichi, Ishida, Susumu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415971/
https://ncbi.nlm.nih.gov/pubmed/28624188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.01.001
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