A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation

OBJECTIVES: This study assessed the efficacy and safety of plecanatide, a guanylate cyclase-C (GC-C) agonist and the first uroguanylin analog approved for the treatment of chronic idiopathic constipation (CIC). METHODS: This phase III, multicenter, double-blind, placebo-controlled study randomized 1...

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Bibliografische gegevens
Gepubliceerd in:Am J Gastroenterol
Hoofdauteurs: Miner Jr, Philip B, Koltun, William D, Wiener, Gregory J, De La Portilla, Marianela, Prieto, Blas, Shailubhai, Kunwar, Layton, Mary Beth, Barrow, Laura, Magnus, Leslie, Griffin, Patrick H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
Onderwerpen:
Functional GI Disorders
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415706/
https://ncbi.nlm.nih.gov/pubmed/28169285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajg.2016.611
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