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HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1

Sodium valporate (VPA), a broad-spectrum inhibitor of histone deacetylases (HDACs), increased ghrelin whereas decreased nesfatin-1 in mice fed normal chow diet or high-fat diet. Alterations in ghrelin and nucleobindin 2/nesfatin-1 were mediated by HDAC5 but not HDAC4. Activation of mTORC1 significan...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Ma, Liangxiao, Tang, Hong, Yin, Yue, Yu, Ruili, Zhao, Jing, Li, Yin, Mulholland, Michael W., Zhang, Weizhen
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414676/
https://ncbi.nlm.nih.gov/pubmed/26357899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1184
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