Activation of mTORC1 signaling in gastric X/A-like cells induces spontaneous pancreatic fibrosis and derangement of glucose metabolism by reducing ghrelin production

BACKGROUND: Pancreatic fibrosis is a pathophysiological process associated with excessive deposition of extracellular matrix in pancreas, leading to reduced insulin secretion and derangement of glucose metabolism. X/A-like cells, a group of unique endocrine cells in gastric oxyntic mucosa, produce a...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:EBioMedicine
Asıl Yazarlar: Yu, Ruili, Li, Ziru, Liu, Shiying, Huwatibieke, Bahetiyaer, Li, Yin, Yin, Yue, Zhang, Weizhen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2018
Konular:
Research paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197745/
https://ncbi.nlm.nih.gov/pubmed/30266297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.09.027
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