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C3d regulates immune checkpoint blockade and enhances antitumor immunity
Despite expression of immunogenic polypeptides, tumors escape immune surveillance by engaging T cell checkpoint regulators and expanding Tregs, among other mechanisms. What orchestrates these controls is unknown. We report that free C3d, a fragment of the third component of complement, inside tumor...
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| Veröffentlicht in: | JCI Insight |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5414554/ https://ncbi.nlm.nih.gov/pubmed/28469081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90201 |
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