DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal sid...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Xu, Xiaowei, Huang, Shijiao, Zhang, Boyan, Huang, Fan, Chi, Wangfei, Fu, Jingyan, Wang, Gang, Li, Si, Jiang, Qing, Zhang, Chuanmao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414174/
https://ncbi.nlm.nih.gov/pubmed/28447620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15164
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