DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal sid...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xu, Xiaowei, Huang, Shijiao, Zhang, Boyan, Huang, Fan, Chi, Wangfei, Fu, Jingyan, Wang, Gang, Li, Si, Jiang, Qing, Zhang, Chuanmao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414174/
https://ncbi.nlm.nih.gov/pubmed/28447620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15164
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