Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda

BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr1, which encodes the Plasmodium falciparum multidrug resistance transporter. In Africa the N86Y and D1246Y polymorphisms have been shown to be selected by treatment, with artemether-lumefantrine (AL)...

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Pubblicato in:Open Forum Infect Dis
Autori principali: Taylor, Aimee R., Flegg, Jennifer A., Holmes, Chris C., Guérin, Philippe J., Sibley, Carol H., Conrad, Melissa D., Dorsey, Grant, Rosenthal, Philip J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Major Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413987/
https://ncbi.nlm.nih.gov/pubmed/28480232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofw229
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