Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda

BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr1, which encodes the Plasmodium falciparum multidrug resistance transporter. In Africa the N86Y and D1246Y polymorphisms have been shown to be selected by treatment, with artemether-lumefantrine (AL)...

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Foilsithe in:Open Forum Infect Dis
Main Authors: Taylor, Aimee R., Flegg, Jennifer A., Holmes, Chris C., Guérin, Philippe J., Sibley, Carol H., Conrad, Melissa D., Dorsey, Grant, Rosenthal, Philip J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Major Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413987/
https://ncbi.nlm.nih.gov/pubmed/28480232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofw229
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