Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda

BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr1, which encodes the Plasmodium falciparum multidrug resistance transporter. In Africa the N86Y and D1246Y polymorphisms have been shown to be selected by treatment, with artemether-lumefantrine (AL)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Open Forum Infect Dis
Prif Awduron: Taylor, Aimee R., Flegg, Jennifer A., Holmes, Chris C., Guérin, Philippe J., Sibley, Carol H., Conrad, Melissa D., Dorsey, Grant, Rosenthal, Philip J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Major Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413987/
https://ncbi.nlm.nih.gov/pubmed/28480232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofw229
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