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The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
As noted by Warburg, many cancer cells depend on the consumption of glucose. We performed a genetic screen to identify factors responsible for glucose addiction and recovered the two subunits of the xCT antiporter (system x(c)(−)), which plays an antioxidant role by exporting glutamate for cystine....
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413954/ https://ncbi.nlm.nih.gov/pubmed/28429737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15074 |
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