The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness

The contribution of MEF2 TFs to the tumorigenic process is still mysterious. Here we clarify that MEF2 can support both pro-oncogenic or tumor suppressive activities depending on the interaction with co-activators or co-repressors partners. Through these interactions MEF2 supervise histone modificat...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Di Giorgio, Eros, Franforte, Elisa, Cefalù, Sebastiano, Rossi, Sabrina, Dei Tos, Angelo Paolo, Brenca, Monica, Polano, Maurizio, Maestro, Roberta, Paluvai, Harikrishnareddy, Picco, Raffaella, Brancolini, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413110/
https://ncbi.nlm.nih.gov/pubmed/28419090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006752
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