Engineered ligand‐based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis

Pathologic angiogenesis is mediated by the coordinated action of the vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR2) signaling axis, along with crosstalk contributed by other receptors, notably α(v)β(3) integrin. We build on earlier work demonstrating...

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Bibliographic Details
Published in:Bioeng Transl Med
Main Authors: Kapur, Shiven, Silverman, Adam P., Ye, Anne Z., Papo, Niv, Jindal, Darren, Blumenkranz, Mark S., Cochran, Jennifer R.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412928/
https://ncbi.nlm.nih.gov/pubmed/28516164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10051
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