Delayed accumulation of H3K27me3 on nascent DNA is essential for recruitment of transcription factors at early stages of stem cell differentiation

Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs during cell differentiation. However, recruitment of all TFs, including pioneer factors, is impeded by condensed H3K27me3-containing chromatin. Single-cell and gene-spec...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Petruk, Svetlana, Cai, Jingli, Sussman, Robyn, Sun, Guizhi, Kovermann, Sina K., Mariani, Samanta A., Calabretta, Bruno, McMahon, Steven B., Brock, Hugh W., Iacovitti, Lorraine, Mazo, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412717/
https://ncbi.nlm.nih.gov/pubmed/28410996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.006
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