In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01

Idiosyncratic ximelagatran-induced hepatotoxicity has been reported to be associated with human leukocyte antigen (HLA)-DRB1*07:01 and ximelagatran has been reported to inhibit the binding of the ligand peptide to HLA-DRB1*07:01 in vitro. In order to predict the possible interaction modes of ximelag...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Hirasawa, Makoto, Hagihara, Katsunobu, Abe, Koji, Ando, Osamu, Hirayama, Noriaki
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412280/
https://ncbi.nlm.nih.gov/pubmed/28338626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18040694
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