HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in ze...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Holland, Petter, Knævelsrud, Helene, Søreng, Kristiane, Mathai, Benan J., Lystad, Alf Håkon, Pankiv, Serhiy, Bjørndal, Gunnveig T., Schultz, Sebastian W., Lobert, Viola H., Chan, Robin B., Zhou, Bowen, Liestøl, Knut, Carlsson, Sven R., Melia, Thomas J., Di Paolo, Gilbert, Simonsen, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412012/
https://ncbi.nlm.nih.gov/pubmed/28004827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13889
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados