Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II

The most polymorphic part of the human genome, the MHC, encodes over 160 proteins of diverse function. Half of them, including the HLA class I and II genes, are directly involved in immune responses. Consequently, the MHC region strongly associates with numerous diseases and clinical therapies. Noto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Res
Prif Awduron: Norman, Paul J., Norberg, Steven J., Guethlein, Lisbeth A., Nemat-Gorgani, Neda, Royce, Thomas, Wroblewski, Emily E., Dunn, Tamsen, Mann, Tobias, Alicata, Claudia, Hollenbach, Jill A., Chang, Weihua, Shults Won, Melissa, Gunderson, Kevin L., Abi-Rached, Laurent, Ronaghi, Mostafa, Parham, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2017
Pynciau:
Method
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411776/
https://ncbi.nlm.nih.gov/pubmed/28360230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.213538.116
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