Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR

The RNA-dependent protein kinase (PKR) has broad antiviral activity inducing translational shutdown of viral and cellular genes and is therefore targeted by various viral proteins to facilitate pathogen propagation. The pleiotropic NS1 protein of influenza A virus acts as silencer of PKR activation...

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Vydáno v:J Virol
Hlavní autoři: Schierhorn, Kristina L., Jolmes, Fabian, Bespalowa, Julia, Saenger, Sandra, Peteranderl, Christin, Dzieciolowski, Julia, Mielke, Maja, Budt, Matthias, Pleschka, Stephan, Herrmann, Andreas, Herold, Susanne, Wolff, Thorsten
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411612/
https://ncbi.nlm.nih.gov/pubmed/28250123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00198-17
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