Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials

Objectives. To investigate changes in neutrophil count and occurrences of infection in RA patients treated with the IL-6 receptor-α inhibitor tocilizumab (TCZ). Methods. Data were pooled from patients who received i.v. TCZ (4 mg/kg + MTX, 8 mg/kg ± DMARDs, 10 mg/kg) or placebo + DMARDs in phase 3/4...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Moots, Robert J., Sebba, Anthony, Rigby, William, Ostor, Andrew, Porter-Brown, Benjamin, Donaldson, Francis, Dimonaco, Sophie, Rubbert-Roth, Andrea, van Vollenhoven, Ronald, Genovese, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410975/
https://ncbi.nlm.nih.gov/pubmed/28013198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kew370
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