APC/C(Cdh1)-Rock2 pathway controls dendritic integrity and memory

Disruption of neuronal morphology contributes to the pathology of neurodegenerative disorders such as Alzheimer’s disease (AD). However, the underlying molecular mechanisms are unknown. Here, we show that postnatal deletion of Cdh1, a cofactor of the anaphase-promoting complex/cyclosome (APC/C) ubiq...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bobo-Jiménez, Verónica, Delgado-Esteban, María, Angibaud, Julie, Sánchez-Morán, Irene, de la Fuente, Antonio, Yajeya, Javier, Nägerl, U. Valentin, Castillo, José, Bolaños, Juan P., Almeida, Angeles
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410848/
https://ncbi.nlm.nih.gov/pubmed/28396402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616024114
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