APC/C(Cdh1)-Rock2 pathway controls dendritic integrity and memory

Disruption of neuronal morphology contributes to the pathology of neurodegenerative disorders such as Alzheimer’s disease (AD). However, the underlying molecular mechanisms are unknown. Here, we show that postnatal deletion of Cdh1, a cofactor of the anaphase-promoting complex/cyclosome (APC/C) ubiq...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bobo-Jiménez, Verónica, Delgado-Esteban, María, Angibaud, Julie, Sánchez-Morán, Irene, de la Fuente, Antonio, Yajeya, Javier, Nägerl, U. Valentin, Castillo, José, Bolaños, Juan P., Almeida, Angeles
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410848/
https://ncbi.nlm.nih.gov/pubmed/28396402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616024114
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