Llwytho...

Entropy redistribution controls allostery in a metalloregulatory protein

Allosteric communication between two ligand-binding sites in a protein is a central aspect of biological regulation that remains mechanistically unclear. Here we show that perturbations in equilibrium picosecond–nanosecond motions impact zinc (Zn)-induced allosteric inhibition of DNA binding by the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Capdevila, Daiana A., Braymer, Joseph J., Edmonds, Katherine A., Wu, Hongwei, Giedroc, David P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410788/
https://ncbi.nlm.nih.gov/pubmed/28348247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620665114
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