The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases

Prion diseases are neurodegenerative pathologies characterized by the accumulation of a protease-resistant form of the cellular prion protein named prion protein scrapie (PrP(Sc)) in the brain. PrP(Sc) accumulation in the endoplasmic reticulum (ER) result in a dysregulated calcium (Ca(2+)) homeostas...

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Bibliographic Details
Published in:Front Aging Neurosci
Main Authors: Shah, Syed Zahid Ali, Zhao, Deming, Hussain, Tariq, Yang, Lifeng
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410568/
https://ncbi.nlm.nih.gov/pubmed/28507517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00120
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