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“Back to a false normality”: new intriguing mechanisms of resistance to PARP inhibitors
Several evidences have shown that BRCA mutations increased tumor-cells sensitivity to PARP inhibitors by synthetic lethality leading to an accelerated development of several compounds targeting the PARP enzymes system as anticancer agents for clinical setting. Most of such compounds have been invest...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5410353/ https://ncbi.nlm.nih.gov/pubmed/28055979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14409 |
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