Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is a highly aggressive neoplasm. We aim to explore the anti-HCC activity by a natural prenylflavonoid icaritin. Icaritin was cytotoxic and pro-apoptotic when added to established (HepG2, KYN-2 and Huh-7 lines) and primary human HCC cells. At the signaling level, icarit...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Lu, Pei-Hua, Chen, Min-Bin, Liu, Yuan-Yuan, Wu, Mian-Hua, Li, Wen-Ting, Wei, Mu-Xin, Liu, Chao-Ying, Qin, Shu-Kui
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410263/
https://ncbi.nlm.nih.gov/pubmed/28206952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15205
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