HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) is the rate-limiting enzyme of ketogenesis. Growing evidence indicates that HMGCS2 may be involved in cancer progression, but its exact role is largely unknown. In this study, we demonstrate that HMGCS2 mRNA expression is associated with...

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Foilsithe in:Oncotarget
Main Authors: Chen, Shih-Wen, Chou, Chiang-Ting, Chang, Cheng-Chi, Li, Yue-Ju, Chen, Szu-Ta, Lin, I-Ching, Kok, Sang-Heng, Cheng, Shih-Jung, Lee, Jang-Jaer, Wu, Tai-Sheng, Kuo, Min-Liang, Lin, Been-Ren
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410236/
https://ncbi.nlm.nih.gov/pubmed/27816970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13006
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