Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling

Activin like kinase-1 (ALK-1) mediates signaling via the transforming growth factor beta (TGFβ) family of ligands. ALK-1 activity promotes endothelial proliferation and migration. Reduced ALK-1 activity is associated with arteriovenous malformations. No studies have examined the effect of global ALK...

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Detalhes bibliográficos
Publicado no:Heart Vessels
Main Authors: Morine, Kevin J., Paruchuri, Vikram, Qiao, Xiaoying, Aronovitz, Mark J., Mackey, Emily E., Buiten, Lyanne, Levine, Jonathan, Ughreja, Keshan, Nepali, Prerna, Blanton, Robert M., Karas, Richard H., Kapur, Navin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410196/
https://ncbi.nlm.nih.gov/pubmed/28213819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00380-017-0955-x
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