Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration

BACKGROUND: Huntington’s disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expe...

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Bibliographic Details
Published in:PeerJ
Main Authors: Kreiner, Grzegorz, Rafa-Zabłocka, Katarzyna, Chmielarz, Piotr, Bagińska, Monika, Nalepa, Irena
Format: Artigo
Language:Inglês
Published: PeerJ Inc. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410142/
https://ncbi.nlm.nih.gov/pubmed/28462043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.3240
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