Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome–like phenotypes

Mutations in the X-linked gene encoding methyl-CpG–binding protein 2 (MeCP2) cause Rett syndrome (RTT), a neurological disorder affecting cognitive development, respiration, and motor function. Genetic restoration of MeCP2 expression reverses RTT-like phenotypes in mice, highlighting the need to sea...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Lamonica, Janine M., Kwon, Deborah Y., Goffin, Darren, Fenik, Polina, Johnson, Brian S., Cui, Yue, Guo, Hengyi, Veasey, Sigrid, Zhou, Zhaolan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409785/
https://ncbi.nlm.nih.gov/pubmed/28394263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90967
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