Idiosyncratic recognition of UUG/UUA codons by modified nucleoside 5-taurinomethyluridine, τm(5)U present at ‘wobble’ position in anticodon loop of tRNA(Leu): A molecular modeling approach

Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm(5)U) at the ‘wobble’ 34(th) position in tRNA(Leu) causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm(5)U(34) specifically recognizes UUG and UUA codons. Structural conseque...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Kamble, Asmita S., Fandilolu, Prayagraj M., Sambhare, Susmit B., Sonawane, Kailas D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409519/
https://ncbi.nlm.nih.gov/pubmed/28453549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176756
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items