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The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

Crossing over between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks that occur throughout the genome. In the major interference-responsive crossover pathway in baker’s yeast, these breaks are resected to form 3' single-strand tails that participate in a...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Manhart, Carol M., Ni, Xiaodan, White, Martin A., Ortega, Joaquin, Surtees, Jennifer A., Alani, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409509/
https://ncbi.nlm.nih.gov/pubmed/28453523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2001164
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