Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1

Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Δ(1)-pyrroline-5-carboxylate (P5C) to proline. Mutations in the PYCR1 gene alter mitochondrial function and cause the connective tissue disorder cutis laxa. Furthermore...

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Udgivet i:J Biol Chem
Main Authors: Christensen, Emily M., Patel, Sagar M., Korasick, David A., Campbell, Ashley C., Krause, Kurt L., Becker, Donald F., Tanner, John J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409489/
https://ncbi.nlm.nih.gov/pubmed/28258219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780288
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