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Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

Partitioning of ATP generation between glycolysis and oxidative phosphorylation is central to cellular bioenergetics but cumbersome to measure. We describe here how rates of ATP generation by each pathway can be calculated from simultaneous measurements of extracellular acidification and oxygen cons...

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Pubblicato in:J Biol Chem
Autori principali: Mookerjee, Shona A., Gerencser, Akos A., Nicholls, David G., Brand, Martin D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409486/
https://ncbi.nlm.nih.gov/pubmed/28270511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.774471
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