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Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition

Absorption of dietary sphingomyelin (SM) requires its initial degradation into ceramide, a process catalyzed by the intestinal enzyme alkaline sphingomyelinase (alk-SMase, NPP7, ENPP7). alk-SMase belongs to the nucleotide pyrophosphatase/phosphodiesterase (NPP) family, the members of which hydrolyze...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Gorelik, Alexei, Liu, Fangyu, Illes, Katalin, Nagar, Bhushan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409475/
https://ncbi.nlm.nih.gov/pubmed/28292932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769273
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