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Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition
Absorption of dietary sphingomyelin (SM) requires its initial degradation into ceramide, a process catalyzed by the intestinal enzyme alkaline sphingomyelinase (alk-SMase, NPP7, ENPP7). alk-SMase belongs to the nucleotide pyrophosphatase/phosphodiesterase (NPP) family, the members of which hydrolyze...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409475/ https://ncbi.nlm.nih.gov/pubmed/28292932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769273 |
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