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Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition

Absorption of dietary sphingomyelin (SM) requires its initial degradation into ceramide, a process catalyzed by the intestinal enzyme alkaline sphingomyelinase (alk-SMase, NPP7, ENPP7). alk-SMase belongs to the nucleotide pyrophosphatase/phosphodiesterase (NPP) family, the members of which hydrolyze...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Gorelik, Alexei, Liu, Fangyu, Illes, Katalin, Nagar, Bhushan
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409475/
https://ncbi.nlm.nih.gov/pubmed/28292932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769273
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