An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

The design of targeted platinum(iv) prodrugs is a very promising approach to enhance the low selectivity of platinum(ii) drugs towards cancerous tissue in order to reduce the impact on healthy tissue and, consequently, the often severe side-effects. Herein, we report a set of mono-functionalized cis...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Mayr, Josef, Heffeter, Petra, Groza, Diana, Galvez, Luis, Koellensperger, Gunda, Roller, Alexander, Alte, Beatrix, Haider, Melanie, Berger, Walter, Kowol, Christian R., Keppler, Bernhard K.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409245/
https://ncbi.nlm.nih.gov/pubmed/28507680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03862j
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