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Polycomb repressive complex 1 provides a molecular explanation for repeat copy number dependency in FSHD muscular dystrophy

Repression of repetitive elements is crucial to preserve genome integrity and has been traditionally ascribed to constitutive heterochromatin pathways. FacioScapuloHumeral Muscular Dystrophy (FSHD), one of the most common myopathies, is characterized by a complex interplay of genetic and epigenetic...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Casa, Valentina, Runfola, Valeria, Micheloni, Stefano, Aziz, Arif, Dilworth, F. Jeffrey, Gabellini, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409123/
https://ncbi.nlm.nih.gov/pubmed/28040729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw426
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