Detection of Immunoglobulin Heavy Chain Gene Clonality by Next-Generation Sequencing for Minimal Residual Disease Monitoring in B-Lymphoblastic Leukemia

Minimal residual disease (MRD) following B-lymphoblastic leukemia (B-ALL) treatment has gained prognostic importance. Clonal immunoglobulin heavy chain (IGH) gene rearrangement is a useful follow-up marker in B-ALL owing to its high positivity rate. We evaluated the performance and clinical applicab...

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Dettagli Bibliografici
Pubblicato in:Ann Lab Med
Autori principali: Shin, Saeam, Hwang, In Sik, Kim, Jieun, Lee, Kyung-A, Lee, Seung-Tae, Choi, Jong Rak
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Korean Society for Laboratory Medicine 2017
Soggetti:
Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409014/
https://ncbi.nlm.nih.gov/pubmed/28445014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3343/alm.2017.37.4.331
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