Inefficient crossover maturation underlies elevated aneuploidy in human female meiosis

Meiosis is the cellular program that underlies gamete formation. For this program, crossovers between homologous chromosomes play an essential mechanical role to ensure regular segregation. We present a detailed study of crossover formation in human male and female meiosis, enabled by modeling analy...

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Bibliographic Details
Published in:Cell
Main Authors: Wang, Shunxin, Hassold, Terry, Hunt, Patricia, White, Martin A., Zickler, Denise, Kleckner, Nancy, Zhang, Liangran
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408880/
https://ncbi.nlm.nih.gov/pubmed/28262352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.002
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