Inefficient crossover maturation underlies elevated aneuploidy in human female meiosis

Meiosis is the cellular program that underlies gamete formation. For this program, crossovers between homologous chromosomes play an essential mechanical role to ensure regular segregation. We present a detailed study of crossover formation in human male and female meiosis, enabled by modeling analy...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Wang, Shunxin, Hassold, Terry, Hunt, Patricia, White, Martin A., Zickler, Denise, Kleckner, Nancy, Zhang, Liangran
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408880/
https://ncbi.nlm.nih.gov/pubmed/28262352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.002
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