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Inefficient crossover maturation underlies elevated aneuploidy in human female meiosis

Meiosis is the cellular program that underlies gamete formation. For this program, crossovers between homologous chromosomes play an essential mechanical role to ensure regular segregation. We present a detailed study of crossover formation in human male and female meiosis, enabled by modeling analy...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wang, Shunxin, Hassold, Terry, Hunt, Patricia, White, Martin A., Zickler, Denise, Kleckner, Nancy, Zhang, Liangran
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408880/
https://ncbi.nlm.nih.gov/pubmed/28262352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.002
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