Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture

Long-term exposure to a mechanical load causes degenerative changes in the disc nucleus pulposus (NP) tissue. A previous study demonstrated that N-cadherin (N-CDH)-mediated signalling can preserve the NP cell phenotype. However, N-CDH expression and the resulting phenotype alteration in NP cells und...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Li, Pei, Zhang, Ruijie, Wang, Liyuan, Gan, Yibo, Xu, Yuan, Song, Lei, Luo, Lei, Zhao, Chen, Zhang, Chengmin, Ouyang, Bin, Tu, Bing, Zhou, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408662/
https://ncbi.nlm.nih.gov/pubmed/28351894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20160582
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