Altered Ca(2+) homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion protein (PrP(Sc)). The molecular mechanisms under...

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Publicat a:Acta Neuropathol Commun
Autors principals: Llorens, Franc, Thüne, Katrin, Sikorska, Beata, Schmitz, Matthias, Tahir, Waqas, Fernández-Borges, Natalia, Cramm, Maria, Gotzmann, Nadine, Carmona, Margarita, Streichenberger, Nathalie, Michel, Uwe, Zafar, Saima, Schuetz, Anna-Lena, Rajput, Ashish, Andréoletti, Olivier, Bonn, Stefan, Fischer, Andre, Liberski, Pawel P., Torres, Juan Maria, Ferrer, Isidre, Zerr, Inga
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408381/
https://ncbi.nlm.nih.gov/pubmed/28449707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0431-y
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