Altered Ca(2+) homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion protein (PrP(Sc)). The molecular mechanisms under...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Neuropathol Commun
Prif Awduron: Llorens, Franc, Thüne, Katrin, Sikorska, Beata, Schmitz, Matthias, Tahir, Waqas, Fernández-Borges, Natalia, Cramm, Maria, Gotzmann, Nadine, Carmona, Margarita, Streichenberger, Nathalie, Michel, Uwe, Zafar, Saima, Schuetz, Anna-Lena, Rajput, Ashish, Andréoletti, Olivier, Bonn, Stefan, Fischer, Andre, Liberski, Pawel P., Torres, Juan Maria, Ferrer, Isidre, Zerr, Inga
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408381/
https://ncbi.nlm.nih.gov/pubmed/28449707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0431-y
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