Altered Ca(2+) homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion protein (PrP(Sc)). The molecular mechanisms under...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Llorens, Franc, Thüne, Katrin, Sikorska, Beata, Schmitz, Matthias, Tahir, Waqas, Fernández-Borges, Natalia, Cramm, Maria, Gotzmann, Nadine, Carmona, Margarita, Streichenberger, Nathalie, Michel, Uwe, Zafar, Saima, Schuetz, Anna-Lena, Rajput, Ashish, Andréoletti, Olivier, Bonn, Stefan, Fischer, Andre, Liberski, Pawel P., Torres, Juan Maria, Ferrer, Isidre, Zerr, Inga
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408381/
https://ncbi.nlm.nih.gov/pubmed/28449707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0431-y
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