Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1(hi) Tfh are important in the GC response, the function of the PD1(lo) Tfh-like subset is unknown. We show that these cells, like the PD1(hi) GC–Tfh, depend upo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Trüb, Marta, Barr, Tom A., Morrison, Vicky L., Brown, Sheila, Caserta, Stefano, Rixon, Jordan, Ivens, Alasdair, Gray, David
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408024/
https://ncbi.nlm.nih.gov/pubmed/28503175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00489
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