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Inferring modulators of genetic interactions with epistatic nested effects models

Maps of genetic interactions can dissect functional redundancies in cellular networks. Gene expression profiles as high-dimensional molecular readouts of combinatorial perturbations provide a detailed view of genetic interactions, but can be hard to interpret if different gene sets respond in differ...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Pirkl, Martin, Diekmann, Madeline, van der Wees, Marlies, Beerenwinkel, Niko, Fröhlich, Holger, Markowetz, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407847/
https://ncbi.nlm.nih.gov/pubmed/28406896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005496
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