Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD

The innate immune system has been implicated in both AKI and CKD. Damaged mitochondria release danger molecules, such as reactive oxygen species, DNA, and cardiolipin, which can cause NLRP3 inflammasome activation and upregulation of IL-18 and IL-1β. It is not known if mitochondrial damage persists...

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Bibliografski detalji
Izdano u:J Am Soc Nephrol
Glavni autori: Szeto, Hazel H., Liu, Shaoyi, Soong, Yi, Seshan, Surya V., Cohen-Gould, Leona, Manichev, Viacheslav, Feldman, Leonard C., Gustafsson, Torgny
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2017
Teme:
Basic Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407729/
https://ncbi.nlm.nih.gov/pubmed/27881606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016070761
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