MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy

Epitopes of phospholipase A2 receptor (PLA2R), the target antigen in idiopathic membranous nephropathy (iMN), must be presented by the HLA–encoded MHC class II molecules to stimulate autoantibody production. A genome–wide association study identified risk alleles at HLA and PLA2R loci, with the top...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Cui, Zhao, Xie, Li-jun, Chen, Fang-jin, Pei, Zhi-yong, Zhang, Li-jie, Qu, Zhen, Huang, Jing, Gu, Qiu-hua, Zhang, Yi-miao, Wang, Xin, Wang, Fang, Meng, Li-qiang, Liu, Gang, Zhou, Xu-jie, Zhu, Li, Lv, Ji-cheng, Liu, Fan, Zhang, Hong, Liao, Yun-hua, Lai, Lu-hua, Ronco, Pierre, Zhao, Ming-hui
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2017
Subjects:
Clinical Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407714/
https://ncbi.nlm.nih.gov/pubmed/27852637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016020114
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