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The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells

PURPOSE: Benzalkonium chloride (BAK) is the most commonly used eye drop preservative. Benzalkonium chloride has been associated with toxic effects such as “dry eye” and trabecular meshwork degeneration, but the underlying biochemical mechanism of ocular toxicity by BAK is unclear. In this study, we...

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Bibliografiske detaljer
Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Datta, Sandipan, Baudouin, Christophe, Brignole-Baudouin, Francoise, Denoyer, Alexandre, Cortopassi, Gino A.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407244/
https://ncbi.nlm.nih.gov/pubmed/28444329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20903
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