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Mutations that Allow SIR2 Orthologs to Function in a NAD(+)-Depleted Environment
Sirtuin enzymes depend on NAD(+) to catalyze protein deacetylation. Therefore, the lowering of NAD(+) during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic...
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| Udgivet i: | Cell Rep |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407064/ https://ncbi.nlm.nih.gov/pubmed/28273448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.031 |
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